A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival

The enzyme UCH-L1 is a neuro-endocrine and germinal center B-cell marker that contributes to the development and aggressive behavior of mature B-cell malignancies. While mutations in this enzyme have been associated with Parkinson’s disease, relatively little is known about the molecular features as...

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Detalles Bibliográficos
Autores principales: Hussain, Sajjad, Bedekovics, Tibor, Ali, Asma, Zaid, Omar, May, Danielle G., Roux, Kyle J., Galardy, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904616/
https://www.ncbi.nlm.nih.gov/pubmed/31839994
http://dx.doi.org/10.1038/s41420-019-0231-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904616/
https://www.ncbi.nlm.nih.gov/pubmed/31839994
http://dx.doi.org/10.1038/s41420-019-0231-1

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