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Customisation and validation of a low-volume plasma renin activity immunoassay: Enabling of regulatory compliant determination in paediatric trials
OBJECTIVES: Investigations of plasma renin activity (PRA) in children are urgently required. Small-volume, regulatory guideline compliant, bioanalytical assays tailored for paediatric application could facilitate to overcome this hurdle. Ethical constraints given e.g. by the European Medicines Agenc...
Autores principales: | Suessenbach, F.K., Tins, J., Burckhardt, B.B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904673/ https://www.ncbi.nlm.nih.gov/pubmed/31867426 http://dx.doi.org/10.1016/j.plabm.2019.e00144 |
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