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SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1

The predominant motor neuron disease in infants and adults is spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS), respectively. SMA is caused by insufficient levels of the Survival Motor Neuron (SMN) protein, which operates as part of the multiprotein SMN complex that includes the...

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Detalles Bibliográficos
Autores principales: Cacciottolo, Rebecca, Ciantar, Joanna, Lanfranco, Maia, Borg, Rebecca M., Vassallo, Neville, Bordonné, Rémy, Cauchi, Ruben J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904755/
https://www.ncbi.nlm.nih.gov/pubmed/31822699
http://dx.doi.org/10.1038/s41598-019-53508-4