Cargando…

Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake

In Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available exhibit several limitations, mainly related to drug toxicity and reduced efficacy in some regions. Miltefosine (MF), the only oral drug available for leishmaniasis treatment, is no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Espada, Caroline R., Magalhães, Rubens M., Cruz, Mario C., Machado, Paulo R., Schriefer, Albert, Carvalho, Edgar M., Hornillos, Valentín, Alves, João M., Cruz, Angela K., Coelho, Adriano C., Uliana, Silvia R.B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904789/ https://www.ncbi.nlm.nih.gov/pubmed/30850347 http://dx.doi.org/10.1016/j.ijpddr.2019.02.005

Ejemplares similares

GENOTYPE CHARACTERIZATION OF Leishmania (Viannia) braziliensis ISOLATED FROM HUMAN AND CANINE BIOPSIES WITH AMERICAN CUTANEOUS LEISHMANIASIS
por: FERREIRA, Lasaro Teixeira, et al.
Publicado: (2015)

Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
por: Caridha, Diana, et al.
Publicado: (2019)

Mining for natural product antileishmanials in a fungal extract library
por: Mbekeani, A.J., et al.
Publicado: (2019)

In-situ immune profile of polymorphic vs. macular Indian Post Kala-azar dermal leishmaniasis
por: Sengupta, Ritika, et al.
Publicado: (2019)

Novel and safe single-dose treatment of cutaneous leishmaniasis with implantable amphotericin B-loaded microparticles
por: Sousa-Batista, Ariane J., et al.
Publicado: (2019)

Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis
por: Van Bocxlaer, Katrien, et al.
Publicado: (2019)

Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis
por: Jaafari, Mahmoud Reza, et al.
Publicado: (2019)

Successful treatment by adding thalidomide to meglumine antimoniate in a case of refractory anthroponotic mucocutaneous leishmaniasis
por: Goyonlo, Vahid Mashayekhi, et al.
Publicado: (2019)

BODY WEIGHT AS A DETERMINANT OF CLINICAL EVOLUTION IN HAMSTERS (Mesocricetus auratus) INFECTED WITH Leishmania (Viannia) panamensis
por: Gómez-Galindo, Ángela María, et al.
Publicado: (2013)

DETECTION OF Leishmania (Viannia) IN Nyssomyia neivai AND Nyssomyia whitmani BY MULTIPLEX POLYMERASE CHAIN REACTION, IN SOUTHERN BRAZIL
por: Neitzke-Abreu, Herintha Coeto, et al.
Publicado: (2014)

Ros3 (Lem3p/CDC50) Gene Dosage Is Implicated in Miltefosine Susceptibility in Leishmania (Viannia) braziliensis Clinical Isolates and in Leishmania (Leishmania) major
por: Espada, Caroline R., et al.
Publicado: (2021)

EVIDENCE OF Leishmania (Leishmania) infantum INFECTION IN DOGS FROM JUIZ DE FORA, MINAS GERAIS STATE, BRAZIL, BASED ON IMMUNOCHROMATOGRAPHIC DUAL-PATH PLATFORM (DPP(®)) AND PCR ASSAYS
por: Castro-Júnior, José Geraldo, et al.
Publicado: (2014)

Effective Genome Editing in Leishmania (Viannia) braziliensis Stably Expressing Cas9 and T7 RNA Polymerase
por: Espada, Caroline R., et al.
Publicado: (2021)

DISTINCT CELLULAR MIGRATION INDUCED BY Leishmania infantum chagasi AND SALIVA FROM Lutzomyia longipalpis IN A HEMORRHAGIC POOL MODEL
por: Vasconcelos, Camila Oliveira, et al.
Publicado: (2014)

Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis
por: Valdivia, Hugo O., et al.
Publicado: (2015)

The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis
por: Oliveira, Walker N., et al.
Publicado: (2021)

Genomic Diversification, Structural Plasticity, and Hybridization in Leishmania (Viannia) braziliensis
por: Patino, Luz H., et al.
Publicado: (2020)

Mucosal Leishmaniasis Caused by Leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon
por: Guerra, Jorge Augusto de Oliveira, et al.
Publicado: (2011)

Miltefosine in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis in Brazil: A Randomized and Controlled Trial
por: Machado, Paulo R., et al.
Publicado: (2010)

APPLICABILITY OF kDNA-PCR FOR ROUTINE DIAGNOSIS OF AMERICAN TEGUMENTARY LEISHMANIASIS IN A TERTIARY REFERENCE HOSPITAL
por: Satow, Marcela M., et al.
Publicado: (2013)

Les effets secondaires du vaccin COVID 19 chez la population du sud du Maroc
por: Aitnasser, K., et al.
Publicado: (2022)

ASPECTS OF THE ECOLOGY OF PHLEBOTOMINES (Diptera: Psychodidae: Phlebotominae) IN AN AREA OF CUTANEOUS LEISHMANIASIS OCCURRENCE, MUNICIPALITY OF ANGRA DOS REIS, COAST OF RIO DE JANEIRO STATE, BRAZIL
por: de Aguiar, Gustavo Marins, et al.
Publicado: (2014)

FACTORS ASSOCIATED TO ADHERENCE TO DIFFERENT TREATMENT SCHEMES WITH MEGLUMINE ANTIMONIATE IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS
por: Ribeiro, Madelon Novato, et al.
Publicado: (2014)

PARTICIPATION OF TICKS IN THE INFECTIOUS CYCLE OF CANINE VISCERAL LEISHMANIASIS, IN TERESINA, PIAUÍ, BRAZIL
por: Campos, José Henrique Furtado, et al.
Publicado: (2014)

MONTENEGRO SKIN TEST AND AGE OF SKIN LESION AS PREDICTORS OF TREATMENT FAILURE IN CUTANEOUS LEISHMANIASIS
por: Antonio, Liliane de Fátima, et al.
Publicado: (2014)

SOUTH AMERICAN COLLABORATION IN SCIENTIFIC PUBLICATIONS ON LEISHMANIASIS: BIBLIOMETRIC ANALYSIS IN SCOPUS (2000-2011)
por: Huamaní, Charles, et al.
Publicado: (2014)

HISTORICAL SERIES OF PATIENTS WITH VISCERAL LEISHMANIASIS TREATED WITH MEGLUMINE ANTIMONIATE IN A HOSPITAL FOR TROPICAL DISEASES, MACEIÓ-AL, BRAZIL
por: Silveira, Lindon Johoson Diniz, et al.
Publicado: (2015)

Evaluation of a Multilocus Sequence Typing (MLST) scheme for Leishmania (Viannia) braziliensis and Leishmania (Viannia) panamensis in Colombia
por: Herrera, Giovanny, et al.
Publicado: (2017)

A dysflagellar mutant of Leishmania (Viannia) braziliensis isolated from a cutaneous leishmaniasis patient
por: Zauli, Rogéria C, et al.
Publicado: (2012)

A Luciferase-Expressing Leishmania braziliensis Line That Leads to Sustained Skin Lesions in BALB/c Mice and Allows Monitoring of Miltefosine Treatment Outcome
por: Coelho, Adriano C., et al.
Publicado: (2016)

Coinfection of Leishmania (Viannia) braziliensis and Streptococcus pneumoniae in Multiple Cutaneous Lesions
por: Cortes, Paulo R., et al.
Publicado: (2016)

The gp63 Gene Cluster Is Highly Polymorphic in Natural Leishmania (Viannia) braziliensis Populations, but Functional Sites Are Conserved
por: Medina, Lilian S., et al.
Publicado: (2016)

Changes in Macrophage Gene Expression Associated with Leishmania (Viannia) braziliensis Infection
por: Ovalle-Bracho, Clemencia, et al.
Publicado: (2015)

Leishmania (Viannia) braziliensis Inositol Phosphorylceramide: Distinctive Sphingoid Base Composition
por: De Castro Levatti, Erica V., et al.
Publicado: (2017)

Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis
por: Sutter, Amanda, et al.
Publicado: (2017)

Chemotaxis in Leishmania (Viannia) braziliensis: Evaluation by the two-chamber capillary assay
por: López, Emilia Díaz, et al.
Publicado: (2021)

Genetic diversity and population structure of Leishmania (Viannia) braziliensis in the Peruvian jungle
por: De los Santos, Maxy B., et al.
Publicado: (2022)

Therapeutic effect of oral quercetin in hamsters infected with Leishmania Viannia braziliensis
por: dos Santos, Rosiane Freire, et al.
Publicado: (2023)

Quand le COVID-19 chatouille les gros vaisseaux … !
por: Guermazi, M., et al.
Publicado: (2021)

Dynamics of American tegumentary leishmaniasis in a highly endemic region for Leishmania (Viannia) braziliensis infection in northeast Brazil
por: Silva, Juliana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gev5rh3a032l3hgou439cr4t1h