Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming

Critically important to the maintenance of the glutathione (GSH) redox cycle are the activities of many selenocysteine-containing GSH metabolizing enzymes whose translation is controlled by the epitranscriptomic writer alkylation repair homolog 8 (ALKBH8). ALKBH8 is a tRNA methyltransferase that met...

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Detalles Bibliográficos
Autores principales: Lee, May Y., Leonardi, Andrea, Begley, Thomas J., Melendez, J. Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904832/
https://www.ncbi.nlm.nih.gov/pubmed/31765888
http://dx.doi.org/10.1016/j.redox.2019.101375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904832/
https://www.ncbi.nlm.nih.gov/pubmed/31765888
http://dx.doi.org/10.1016/j.redox.2019.101375

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