Induction of G0/G1 phase arrest and apoptosis by CRISPR/Cas9-mediated knockout of CDK2 in A375 melanocytes

Cutaneous melanoma is one of the most common malignant skin tumors, with a continuously increasing incidence. Cyclin-dependent kinase (CDK) 2 is a key regulator of G1-S transition and modulation of G2 progression; however, its role in cancer is a matter of debate. In the present study, a lentivirus...

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Detalles Bibliográficos
Autores principales: Liu, Houguang, Li, Zheng, Huo, Shanshan, Wei, Qiongling, Ge, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904871/
https://www.ncbi.nlm.nih.gov/pubmed/31832188
http://dx.doi.org/10.3892/mco.2019.1952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904871/
https://www.ncbi.nlm.nih.gov/pubmed/31832188
http://dx.doi.org/10.3892/mco.2019.1952

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