An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats

BACKGROUND: Injectable in situ gel (ISG) systems suffer from high initial drug release that may result in toxic effects. OBJECTIVE: This work aimed to develop an injectable sustained release rosuvastatin (RSV) ISG formulation with minimum initial drug burst and improved hyperlipidemic efficacy. METH...

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Detalles Bibliográficos
Autores principales: Ahmed, Tarek A, Mussari, Mohammed A, Abdel-Hady, Seham El-Sayed, El-Say, Khalid M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904902/
https://www.ncbi.nlm.nih.gov/pubmed/31839704
http://dx.doi.org/10.2147/DDDT.S224442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904902/
https://www.ncbi.nlm.nih.gov/pubmed/31839704
http://dx.doi.org/10.2147/DDDT.S224442

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