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An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats
BACKGROUND: Injectable in situ gel (ISG) systems suffer from high initial drug release that may result in toxic effects. OBJECTIVE: This work aimed to develop an injectable sustained release rosuvastatin (RSV) ISG formulation with minimum initial drug burst and improved hyperlipidemic efficacy. METH...
Autores principales: | Ahmed, Tarek A, Mussari, Mohammed A, Abdel-Hady, Seham El-Sayed, El-Say, Khalid M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904902/ https://www.ncbi.nlm.nih.gov/pubmed/31839704 http://dx.doi.org/10.2147/DDDT.S224442 |
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