Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

Human Alzheimer’s disease (AD) brains and transgenic AD mouse models manifest hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that represents the major pathophysiological correlate of cognitive decline. However, the underlying mechanism for this excessive excit...

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Detalles Bibliográficos
Autores principales: Ghatak, Swagata, Dolatabadi, Nima, Trudler, Dorit, Zhang, XiaoTong, Wu, Yin, Mohata, Madhav, Ambasudhan, Rajesh, Talantova, Maria, Lipton, Stuart A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905854/
https://www.ncbi.nlm.nih.gov/pubmed/31782729
http://dx.doi.org/10.7554/eLife.50333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905854/
https://www.ncbi.nlm.nih.gov/pubmed/31782729
http://dx.doi.org/10.7554/eLife.50333

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