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NS1 DNA vaccination protects against Zika infection through T cell–mediated immunity in immunocompetent mice

The causal association of Zika virus (ZIKV) with microcephaly, congenital malformations in infants, and Guillain-Barré syndrome in adults highlights the need for effective vaccines. Thus far, efforts to develop ZIKV vaccines have focused on the viral envelope. ZIKV NS1 as a vaccine immunogen has not...

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Detalles Bibliográficos
Autores principales: Grubor-Bauk, B., Wijesundara, D. K., Masavuli, M., Abbink, P., Peterson, R. L., Prow, N. A., Larocca, R. A., Mekonnen, Z. A., Shrestha, A., Eyre, N. S., Beard, M. R., Gummow, J., Carr, J., Robertson, S. A., Hayball, J. D., Barouch, D. H., Gowans, E. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905874/
https://www.ncbi.nlm.nih.gov/pubmed/31844662
http://dx.doi.org/10.1126/sciadv.aax2388