Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain

RNA splicing is a key mechanism linking genetic variation with psychiatric disorders. Splicing profiles are particularly diverse in brain and difficult to accurately identify and quantify. We developed a new approach to address this challenge, combining long-range PCR and nanopore sequencing with a...

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Detalles Bibliográficos
Autores principales: Clark, Michael B., Wrzesinski, Tomasz, Garcia, Aintzane B., Hall, Nicola A. L., Kleinman, Joel E., Hyde, Thomas, Weinberger, Daniel R., Harrison, Paul J., Haerty, Wilfried, Tunbridge, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906184/
https://www.ncbi.nlm.nih.gov/pubmed/31695164
http://dx.doi.org/10.1038/s41380-019-0583-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906184/
https://www.ncbi.nlm.nih.gov/pubmed/31695164
http://dx.doi.org/10.1038/s41380-019-0583-1

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