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G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor and is involved in the innate immune response against RNA viruses infection. Here, we demonstrate that the Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a positive regulator of the RIG-I-mediated...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906297/ https://www.ncbi.nlm.nih.gov/pubmed/31827077 http://dx.doi.org/10.1038/s41419-019-2178-9 |
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author | Yang, Wenping Ru, Yi Ren, Jingjing Bai, Juncui Wei, Junshu Fu, Shaozu Liu, Xiangtao Li, Dan Zheng, Haixue |
author_facet | Yang, Wenping Ru, Yi Ren, Jingjing Bai, Juncui Wei, Junshu Fu, Shaozu Liu, Xiangtao Li, Dan Zheng, Haixue |
author_sort | Yang, Wenping |
collection | PubMed |
description | Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor and is involved in the innate immune response against RNA viruses infection. Here, we demonstrate that the Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a positive regulator of the RIG-I-mediated signaling pathway. G3BP1-deficient cells inhibited RNA virus-triggered induction of downstream antiviral genes. Furthermore, we found that G3BP1 inhibited the replication of Sendai virus and vesicular stomatitis virus, indicating a positive regulation of G3BP1 to cellular antiviral responses. Mechanistically, G3BP1 formed a complex with RNF125 and RIG-I, leading to decreased RNF125 via its auto-ubiquitination; thus, promoting expression of RIG-I. Overall, the results suggest a novel mechanism for G3BP1 in the positive regulation of antiviral signaling mediated by RIG-I. |
format | Online Article Text |
id | pubmed-6906297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69062972019-12-12 G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response Yang, Wenping Ru, Yi Ren, Jingjing Bai, Juncui Wei, Junshu Fu, Shaozu Liu, Xiangtao Li, Dan Zheng, Haixue Cell Death Dis Article Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor and is involved in the innate immune response against RNA viruses infection. Here, we demonstrate that the Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a positive regulator of the RIG-I-mediated signaling pathway. G3BP1-deficient cells inhibited RNA virus-triggered induction of downstream antiviral genes. Furthermore, we found that G3BP1 inhibited the replication of Sendai virus and vesicular stomatitis virus, indicating a positive regulation of G3BP1 to cellular antiviral responses. Mechanistically, G3BP1 formed a complex with RNF125 and RIG-I, leading to decreased RNF125 via its auto-ubiquitination; thus, promoting expression of RIG-I. Overall, the results suggest a novel mechanism for G3BP1 in the positive regulation of antiviral signaling mediated by RIG-I. Nature Publishing Group UK 2019-12-11 /pmc/articles/PMC6906297/ /pubmed/31827077 http://dx.doi.org/10.1038/s41419-019-2178-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yang, Wenping Ru, Yi Ren, Jingjing Bai, Juncui Wei, Junshu Fu, Shaozu Liu, Xiangtao Li, Dan Zheng, Haixue G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response |
title | G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response |
title_full | G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response |
title_fullStr | G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response |
title_full_unstemmed | G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response |
title_short | G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response |
title_sort | g3bp1 inhibits rna virus replication by positively regulating rig-i-mediated cellular antiviral response |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906297/ https://www.ncbi.nlm.nih.gov/pubmed/31827077 http://dx.doi.org/10.1038/s41419-019-2178-9 |
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