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A higher throughput assay for quantification of melphalan-induced DNA damage in peripheral blood mononuclear cells

Inter-individual differences in DNA adduct formation and repair influence the response to melphalan treatment, however, further clinical investigation of this variability requires a logistically feasible and reproducible bioassay. Our improved fluorescence-based QPCR-block assay is robust, has good...

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Detalles Bibliográficos
Autores principales:	van Kan, Maia, Burns, Kathryn E., Browett, Peter, Helsby, Nuala A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906414/ https://www.ncbi.nlm.nih.gov/pubmed/31827154 http://dx.doi.org/10.1038/s41598-019-55161-3

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