PINK1 phosphorylates ubiquitin predominantly in astrocytes

Loss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved...

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Detalles Bibliográficos
Autores principales: Barodia, Sandeep K., McMeekin, Laura J., Creed, Rose B., Quinones, Elijah K., Cowell, Rita M., Goldberg, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906478/
https://www.ncbi.nlm.nih.gov/pubmed/31840043
http://dx.doi.org/10.1038/s41531-019-0101-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906478/
https://www.ncbi.nlm.nih.gov/pubmed/31840043
http://dx.doi.org/10.1038/s41531-019-0101-9

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