Development of an in silico prediction system of human renal excretion and clearance from chemical structure information incorporating fraction unbound in plasma as a descriptor

Prediction of pharmacokinetic profiles of new chemical entities is essential in drug development to minimize the risks of potential withdrawals. The excretion of unchanged compounds by the kidney constitutes a major route in drug elimination and plays an important role in pharmacokinetics. Herein, w...

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Detalles Bibliográficos
Autores principales: Watanabe, Reiko, Ohashi, Rikiya, Esaki, Tsuyoshi, Kawashima, Hitoshi, Natsume-Kitatani, Yayoi, Nagao, Chioko, Mizuguchi, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906481/
https://www.ncbi.nlm.nih.gov/pubmed/31827176
http://dx.doi.org/10.1038/s41598-019-55325-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906481/
https://www.ncbi.nlm.nih.gov/pubmed/31827176
http://dx.doi.org/10.1038/s41598-019-55325-1

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