Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models

DNA-dependent protein kinase (DNA-PK) has been shown to play a crucial role in repair of DNA double-strand breaks, facilitating nonhomologous end-joining. DNA-PK inhibitors have the potential to block DNA repair and therefore enhance DNA-damaging agents. M3814 is a DNA-PK inhibitor that has shown pr...

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Detalles Bibliográficos
Autores principales: Wise, Hannah C., Iyer, Gopakumar V., Moore, Kathleen, Temkin, Sarah M., Gordon, Sarah, Aghajanian, Carol, Grisham, Rachel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906487/
https://www.ncbi.nlm.nih.gov/pubmed/31827119
http://dx.doi.org/10.1038/s41598-019-54796-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906487/
https://www.ncbi.nlm.nih.gov/pubmed/31827119
http://dx.doi.org/10.1038/s41598-019-54796-6

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