Improving the odds of drug development success through human genomics: modelling study

Lack of efficacy in the intended disease indication is the major cause of clinical phase drug development failure. Explanations could include the poor external validity of pre-clinical (cell, tissue, and animal) models of human disease and the high false discovery rate (FDR) in preclinical science....

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Detalles Bibliográficos
Autores principales: Hingorani, Aroon D., Kuan, Valerie, Finan, Chris, Kruger, Felix A., Gaulton, Anna, Chopade, Sandesh, Sofat, Reecha, MacAllister, Raymond J., Overington, John P., Hemingway, Harry, Denaxas, Spiros, Prieto, David, Casas, Juan Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906499/
https://www.ncbi.nlm.nih.gov/pubmed/31827124
http://dx.doi.org/10.1038/s41598-019-54849-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906499/
https://www.ncbi.nlm.nih.gov/pubmed/31827124
http://dx.doi.org/10.1038/s41598-019-54849-w

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