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C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis

It is important to understand how the disease process affects the metabolic pathways in amyotrophic lateral sclerosis and whether these pathways can be manipulated to ameliorate disease progression. To analyse the basis of the metabolic defect in amyotrophic lateral sclerosis we used a phenotypic me...

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Detalles Bibliográficos
Autores principales: Allen, Scott P, Hall, Benjamin, Woof, Ryan, Francis, Laura, Gatto, Noemi, Shaw, Allan C, Myszczynska, Monika, Hemingway, Jordan, Coldicott, Ian, Willcock, Amelia, Job, Lucy, Hughes, Rachel M, Boschian, Camilla, Bayatti, Nadhim, Heath, Paul R, Bandmann, Oliver, Mortiboys, Heather, Ferraiuolo, Laura, Shaw, Pamela J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906594/
https://www.ncbi.nlm.nih.gov/pubmed/31647549
http://dx.doi.org/10.1093/brain/awz302