Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

BACKGROUND: Hedgehog (Hh) signaling is essential for osteoblast differentiation of mesenchymal progenitors during endochondral bone formation. However, the critical role of Hh signaling during adult bone remodeling remains to be elucidated. METHODS: A Smoothened (SMO) antagonist/Hedgehog inhibitor,...

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Detalles Bibliográficos
Autores principales: AlMuraikhi, Nihal, Almasoud, Nuha, Binhamdan, Sarah, Younis, Ghaydaa, Ali, Dalia, Manikandan, Muthurangan, Vishnubalaji, Radhakrishnan, Atteya, Muhammad, Siyal, Abdulaziz, Alfayez, Musaad, Aldahmash, Abdullah, Kassem, Moustapha, Alajez, Nehad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907053/
https://www.ncbi.nlm.nih.gov/pubmed/31871467
http://dx.doi.org/10.1155/2019/3435901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907053/
https://www.ncbi.nlm.nih.gov/pubmed/31871467
http://dx.doi.org/10.1155/2019/3435901

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