Search-and-replace genome editing without double-strand breaks or donor DNA

Most genetic variants that contribute to disease(1) are challenging to correct efficiently and without excess byproducts(2–5). Here we describe prime editing, a versatile and precise genome editing method that directly writes new genetic information into a specified DNA site using a catalytically im...

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Detalles Bibliográficos
Autores principales: Anzalone, Andrew V., Randolph, Peyton B., Davis, Jessie R., Sousa, Alexander A., Koblan, Luke W., Levy, Jonathan M., Chen, Peter J., Wilson, Christopher, Newby, Gregory A., Raguram, Aditya, Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907074/
https://www.ncbi.nlm.nih.gov/pubmed/31634902
http://dx.doi.org/10.1038/s41586-019-1711-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907074/
https://www.ncbi.nlm.nih.gov/pubmed/31634902
http://dx.doi.org/10.1038/s41586-019-1711-4

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