Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy

BACKGROUND: Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane protein sarcospan (SSPN) in the DMD mdx mouse model significantly reduces disease pathology by restoring membrane adhesion. Identifying...

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Detalles Bibliográficos
Autores principales: Shu, Cynthia, Kaxon-Rupp, Ariana N., Collado, Judd R., Damoiseaux, Robert, Crosbie, Rachelle H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907331/
https://www.ncbi.nlm.nih.gov/pubmed/31831063
http://dx.doi.org/10.1186/s13395-019-0218-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907331/
https://www.ncbi.nlm.nih.gov/pubmed/31831063
http://dx.doi.org/10.1186/s13395-019-0218-x

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