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Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Multiple Sclerosis (MS) is the most common cause of acquired neurological disability in young adults, pathologically characterized by leukocyte infiltration of the central nervous system, demyelination of the white and grey matter, and subsequent axonal loss. Microglia are proposed to play a role in...

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Detalles Bibliográficos
Autores principales: van Wageningen, Thecla A., Vlaar, Eva, Kooij, Gijs, Jongenelen, Cornelis A. M., Geurts, Jeroen J. G., van Dam, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907356/
https://www.ncbi.nlm.nih.gov/pubmed/31829283
http://dx.doi.org/10.1186/s40478-019-0850-z