Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation

Members of the Fanconi anemia (FA) protein family are involved in multiple cellular processes including response to DNA damage and oxidative stress. Here we show that a major FA protein, Fancd2, plays a role in mitochondrial biosynthesis through regulation of mitochondrial translation. Fancd2 intera...

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Detalles Bibliográficos
Autores principales: Chatla, Srinivas, Du, Wei, Wilson, Andrew F., Ruhikanta Meetei, Amom, Pang, Qishen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907690/
https://www.ncbi.nlm.nih.gov/pubmed/31472450
http://dx.doi.org/10.1016/j.scr.2019.101550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907690/
https://www.ncbi.nlm.nih.gov/pubmed/31472450
http://dx.doi.org/10.1016/j.scr.2019.101550

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