Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model

Schistosoma mansoni threatens hundreds of millions of people in >50 countries. Schistosomulae migrate through the lung and adult worms reside in blood vessels adjacent to the intestinal mucosa. Current candidate vaccines aren’t designed to elicit a mucosal response. We have repurposed an attenuat...

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Detalles Bibliográficos
Autores principales: Hassan, Adam S., Zelt, Nicholas H., Perera, Dilhan J., Ndao, Momar, Ward, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907844/
https://www.ncbi.nlm.nih.gov/pubmed/31790394
http://dx.doi.org/10.1371/journal.pntd.0007490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907844/
https://www.ncbi.nlm.nih.gov/pubmed/31790394
http://dx.doi.org/10.1371/journal.pntd.0007490

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