MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair

Through its ability to bind the ends of poly(ADP-ribose) (PAR) chains, the function of the histone variant macroH2A1.1, including its ability to regulate transcription, is coupled to PAR polymerases (PARPs). PARP1 also has a major role in DNA damage response (DDR) signaling, and our results show tha...

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Detalles Bibliográficos
Autores principales: Ruiz, Penelope D., Hamilton, Gregory A., Park, Jong Woo, Gamble, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908255/
https://www.ncbi.nlm.nih.gov/pubmed/31636161
http://dx.doi.org/10.1128/MCB.00230-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908255/
https://www.ncbi.nlm.nih.gov/pubmed/31636161
http://dx.doi.org/10.1128/MCB.00230-19

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