Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a drug that is widely used for immunosuppression in organ transplantation and autoimmune diseases, as well as anticancer chemotherapy. It inhibits IMP dehydrogenase, a rate-limiting enzyme in de novo synthesis of guanidine nu...

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Detalles Bibliográficos
Autores principales: Jurkiewicz, Aneta, Leśniewska, Ewa, Cieśla, Małgorzata, Gorjão, Neuton, Kantidakis, Theodoros, White, Robert J., Boguta, Magdalena, Graczyk, Damian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908259/
https://www.ncbi.nlm.nih.gov/pubmed/31658995
http://dx.doi.org/10.1128/MCB.00294-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908259/
https://www.ncbi.nlm.nih.gov/pubmed/31658995
http://dx.doi.org/10.1128/MCB.00294-19

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