Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain

Research indicates that neurosteroids are locally synthesized in the central nervous system and play an important modulatory role in nociception. While the neurosteroidogenic enzyme, cytochrome P450 side-chain cleavage enzyme (P450scc), is the initiating enzyme of steroidogenesis, P450scc has not be...

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Detalles Bibliográficos
Autores principales: Choi, Sheu-Ran, Beitz, Alvin J., Lee, Jang-Hern
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908476/
https://www.ncbi.nlm.nih.gov/pubmed/31866864
http://dx.doi.org/10.3389/fphar.2019.01439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908476/
https://www.ncbi.nlm.nih.gov/pubmed/31866864
http://dx.doi.org/10.3389/fphar.2019.01439

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