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3β, 6β-dichloro-5-hydroxy-5α-cholestane facilitates neuronal development through modulating TrkA signaling regulated proteins in primary hippocampal neuron

Potentiating neuritogenesis through pharmacological intervention might hold therapeutic promise in neurodegenerative disorders and acute brain injury. Here, we investigated the novel neuritogenic potentials of a steroidal chlorohydrin, 3β, 6β-dichloro-5-hydroxy-5α-cholestane (hereafter, SCH) and the...

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Detalles Bibliográficos
Autores principales: Hannan, Md. Abdul, Haque, Md. Nazmul, Dash, Raju, Alam, Mahboob, Moon, Il Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908615/
https://www.ncbi.nlm.nih.gov/pubmed/31831796
http://dx.doi.org/10.1038/s41598-019-55364-8