Cargando…

3β, 6β-dichloro-5-hydroxy-5α-cholestane facilitates neuronal development through modulating TrkA signaling regulated proteins in primary hippocampal neuron

Potentiating neuritogenesis through pharmacological intervention might hold therapeutic promise in neurodegenerative disorders and acute brain injury. Here, we investigated the novel neuritogenic potentials of a steroidal chlorohydrin, 3β, 6β-dichloro-5-hydroxy-5α-cholestane (hereafter, SCH) and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hannan, Md. Abdul, Haque, Md. Nazmul, Dash, Raju, Alam, Mahboob, Moon, Il Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908615/ https://www.ncbi.nlm.nih.gov/pubmed/31831796 http://dx.doi.org/10.1038/s41598-019-55364-8

Ejemplares similares

6β-Acetamido-5α-hydroxycholestan-3β-yl acetate
por: Pinto, R. M.A., et al.
Publicado: (2008)

Neuronal Differentiation and Outgrowth Effect of Thymol in Trachyspermum ammi Seed Extract via BDNF/TrkB Signaling Pathway in Prenatal Maternal Supplementation and Primary Hippocampal Culture
por: Timalsina, Binod, et al.
Publicado: (2023)

Gelidium amansii Attenuates Hypoxia/Reoxygenation-Induced Oxidative Injury in Primary Hippocampal Neurons through Suppressing GluN2B Expression
por: Hannan, Md. Abdul, et al.
Publicado: (2020)

3β-Chloro-5α-cholestan-6-one
por: Yusufzai, Samina Khan, et al.
Publicado: (2012)

TrkA Co-Receptors: The Janus Face of TrkA?
por: Trouvilliez, Sarah, et al.
Publicado: (2023)

Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System
por: Hannan, Md. Abdul, et al.
Publicado: (2020)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
por: Mason, Ashley J., et al.
Publicado: (2023)

TrkA(+) Neurons Induce Pathologic Regeneration After Soft Tissue Trauma
por: Cherief, Masnsen, et al.
Publicado: (2022)

Exploration of Binding Affinities of a 3β,6β-Diacetoxy-5α-cholestan-5-ol with Human Serum Albumin: Insights from Synthesis, Characterization, Crystal Structure, Antioxidant and Molecular Docking
por: Alam, Mahboob
Publicado: (2023)

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
por: Marsh, H. Nicholas, et al.
Publicado: (2003)

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization
por: O-Sullivan, InSug, et al.
Publicado: (2022)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation
por: Josephy-Hernandez, Sylvia, et al.
Publicado: (2019)

Sprouty4 Is an Endogenous Negative Modulator of TrkA Signaling and Neuronal Differentiation Induced by NGF
por: Alsina, Fernando C., et al.
Publicado: (2012)

Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function
por: Connor, Blaine, et al.
Publicado: (2023)

Ectopic trkA expression mediates a NGF survival response in NGF- independent sensory neurons but not in parasympathetic neurons
Publicado: (1993)

Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons
por: Zheng, Xiaochun, et al.
Publicado: (2016)

Rapid Retrograde Tyrosine Phosphorylation of trkA and Other Proteins in Rat Sympathetic Neurons in Compartmented Cultures
por: Senger, Donna L., et al.
Publicado: (1997)

NGF and Neurotrophin-3 Both Activate TrkA on Sympathetic Neurons but Differentially Regulate Survival and Neuritogenesis
por: Belliveau, Daniel J., et al.
Publicado: (1997)

P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors
por: Aloyz, Raquel S., et al.
Publicado: (1998)

3β-Acetoxy-5α-cholestan-6-one 2-cyanoacetylhydrazone
por: Yusufzai, Samina Khan, et al.
Publicado: (2012)

NGF – the TrkA to successful pain treatment
por: Kumar, Vinayak, et al.
Publicado: (2012)

6-Hydroxyimino-5α-cholestane
por: Uzzaman, Shams, et al.
Publicado: (2012)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells
por: Lin, Ching-Yu, et al.
Publicado: (2013)

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons
por: Latina, Valentina, et al.
Publicado: (2017)

3β-Acetoxy-6-hydroxyiminocholestane
por: Ketuly, Kamal Aziz, et al.
Publicado: (2011)

Synthesis and antiviral activity of sulfated and acetylated derivatives of 2β,3α-dihydroxy-5α-cholestane
por: Santos, Gustavo A.Garrido, et al.
Publicado: (2003)

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors
por: Brahimi, Fouad, et al.
Publicado: (2014)

TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition
por: Franco, María Luisa, et al.
Publicado: (2021)

3,5-Dichloro-2-hydroxybenzaldehyde
por: Fan, Ying, et al.
Publicado: (2008)

NGF sensitizes TrkA SH-SY5Y neuroblastoma cells to TRAIL-induced apoptosis
por: Ruggeri, P, et al.
Publicado: (2016)

Transcytosis of TrkA leads to diversification of dendritic signaling endosomes
por: Barford, Kelly, et al.
Publicado: (2018)

TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal
por: Majdan, Marta, et al.
Publicado: (2001)

Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro‐cardiac junction
por: Dokshokova, Lolita, et al.
Publicado: (2022)

3β-Chloro-6-[2-(2-cyanoacetyl)hydrazin-1-ylidene]-5α-cholestane
por: Yusufzai, Samina Khan, et al.
Publicado: (2012)

The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19
por: Usai, Carla, et al.
Publicado: (2022)

Src-dependent TrkA Transactivation Is Required for Pituitary Adenylate Cyclase-activating Polypeptide 38-mediated Rit Activation and Neuronal Differentiation
por: Shi, Geng-Xian, et al.
Publicado: (2010)

hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay
por: Triaca, Viviana, et al.
Publicado: (2020)

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances
por: Hannan, Md. Abdul, et al.
Publicado: (2020)

NGF-stimulated retrograde transport of trkA in the mammalian nervous system
Publicado: (1995)

NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts
por: Pryor, Shona, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_74llgi30n8fi76cjh4qndgmj7q