TRPV1 activity and substance P release are required for corneal cold nociception

As a protective mechanism, the cornea is sensitive to noxious stimuli. Here, we show that in mice, a high proportion of corneal TRPM8(+) cold-sensing fibers express the heat-sensitive TRPV1 channel. Despite its insensitivity to cold, TRPV1 enhances membrane potential changes and electrical firing of...

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Detalles Bibliográficos
Autores principales: Li, Fengxian, Yang, Weishan, Jiang, Haowu, Guo, Changxiong, Huang, Andrew J. W., Hu, Hongzhen, Liu, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908618/
https://www.ncbi.nlm.nih.gov/pubmed/31831729
http://dx.doi.org/10.1038/s41467-019-13536-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908618/
https://www.ncbi.nlm.nih.gov/pubmed/31831729
http://dx.doi.org/10.1038/s41467-019-13536-0

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