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ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons
Diseased and injured tendons develop fibrosis, driven by factors including TGF-β, BMPs and CTGF. IL-1β and its signal transducer Erk1/2 are known to regulate TGF-β expression in animal tendons. We utilised tissues and cells isolated from patients with shoulder tendon tears and tendons of healthy vol...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908634/ https://www.ncbi.nlm.nih.gov/pubmed/31831776 http://dx.doi.org/10.1038/s41598-019-55387-1 |