ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons

Diseased and injured tendons develop fibrosis, driven by factors including TGF-β, BMPs and CTGF. IL-1β and its signal transducer Erk1/2 are known to regulate TGF-β expression in animal tendons. We utilised tissues and cells isolated from patients with shoulder tendon tears and tendons of healthy vol...

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Detalles Bibliográficos
Autores principales: Morita, Wataru, Snelling, Sarah J. B., Wheway, Kim, Watkins, Bridget, Appleton, Louise, Carr, Andrew J., Dakin, Stephanie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908634/
https://www.ncbi.nlm.nih.gov/pubmed/31831776
http://dx.doi.org/10.1038/s41598-019-55387-1

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