Pericytes: Problems and Promises for CNS Repair
Microvascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also imp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908836/ https://www.ncbi.nlm.nih.gov/pubmed/31866833 http://dx.doi.org/10.3389/fncel.2019.00546 |
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author | Laredo, Fabio Plebanski, Julia Tedeschi, Andrea |
author_facet | Laredo, Fabio Plebanski, Julia Tedeschi, Andrea |
author_sort | Laredo, Fabio |
collection | PubMed |
description | Microvascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also implicated in a variety of diseases, pericytes represent promising targets that can be manipulated for therapeutic gain. Here, we review the role of pericytes in angiogenesis, blood-brain barrier (BBB) function, neuroinflammation, tissue fibrosis, axon regeneration failure, and neurodegeneration. In addition, we outline strategies altering pericyte behavior to point out problems and promises for axon regeneration and central nervous system (CNS) repair following injury or disease. |
format | Online Article Text |
id | pubmed-6908836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69088362019-12-20 Pericytes: Problems and Promises for CNS Repair Laredo, Fabio Plebanski, Julia Tedeschi, Andrea Front Cell Neurosci Cellular Neuroscience Microvascular complications are often associated with slow and progressive damage of various organs. Pericytes are multi-functional mural cells of the microcirculation that control blood flow, vascular permeability and homeostasis. Whereas accumulating evidence suggests that these cells are also implicated in a variety of diseases, pericytes represent promising targets that can be manipulated for therapeutic gain. Here, we review the role of pericytes in angiogenesis, blood-brain barrier (BBB) function, neuroinflammation, tissue fibrosis, axon regeneration failure, and neurodegeneration. In addition, we outline strategies altering pericyte behavior to point out problems and promises for axon regeneration and central nervous system (CNS) repair following injury or disease. Frontiers Media S.A. 2019-12-06 /pmc/articles/PMC6908836/ /pubmed/31866833 http://dx.doi.org/10.3389/fncel.2019.00546 Text en Copyright © 2019 Laredo, Plebanski and Tedeschi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Laredo, Fabio Plebanski, Julia Tedeschi, Andrea Pericytes: Problems and Promises for CNS Repair |
title | Pericytes: Problems and Promises for CNS Repair |
title_full | Pericytes: Problems and Promises for CNS Repair |
title_fullStr | Pericytes: Problems and Promises for CNS Repair |
title_full_unstemmed | Pericytes: Problems and Promises for CNS Repair |
title_short | Pericytes: Problems and Promises for CNS Repair |
title_sort | pericytes: problems and promises for cns repair |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908836/ https://www.ncbi.nlm.nih.gov/pubmed/31866833 http://dx.doi.org/10.3389/fncel.2019.00546 |
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