Silencing of CHFR Sensitizes Gastric Carcinoma to PARP Inhibitor Treatment

CHFR is a tumor suppressor that not only recognizes poly(ADP-ribosylation) (PARylation) signals at the sites of DNA damage but also is downregulated in many types of cancer. However, the underlying mechanism linking its role in PARylation-mediated DNA damage repair and tumor suppression is unclear....

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Detalles Bibliográficos
Autores principales: Li, Yuan, Shi, Yanyan, Wang, Xiumin, Yu, Xiaochun, Wu, Chen, Ding, Shigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909066/
https://www.ncbi.nlm.nih.gov/pubmed/31812083
http://dx.doi.org/10.1016/j.tranon.2019.10.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909066/
https://www.ncbi.nlm.nih.gov/pubmed/31812083
http://dx.doi.org/10.1016/j.tranon.2019.10.004

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