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Atroposelective Synthesis of Biaryl Diamines and Amino Alcohols via Chiral Phosphoric Acid Catalyzed para-Aminations of Anilines and Phenols

A versatile method for atroposelective synthesis of chiral biaryl diamines and amino alcohols has been developed via para-amination of anilines and phenols with azodicarboxylates enabled by chiral phosphoric acid catalysis. Meanwhile, highly efficient kinetic resolution of the racemic biaryl aniline...

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Detalles Bibliográficos
Autores principales: Wang, Donglei, Liu, Wei, Tang, Mengyao, Yu, Na, Yang, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909093/
https://www.ncbi.nlm.nih.gov/pubmed/31785557
http://dx.doi.org/10.1016/j.isci.2019.11.024