Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites

Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. They bind to mRNA splicing-related proteins to induce a widesp...

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Detalles Bibliográficos
Autores principales: Kurata, Masashi, Fujiwara, Naoko, Fujita, Ken-ichi, Yamanaka, Yasutaka, Seno, Shigeto, Kobayashi, Hisato, Miyamae, Yusaku, Takahashi, Nobuyuki, Shibuya, Yasuyuki, Masuda, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909097/
https://www.ncbi.nlm.nih.gov/pubmed/31809999
http://dx.doi.org/10.1016/j.isci.2019.11.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909097/
https://www.ncbi.nlm.nih.gov/pubmed/31809999
http://dx.doi.org/10.1016/j.isci.2019.11.033

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