Cargando…

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization

Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of ex vivo cell-based gene therapy with stable expression of human pigment epithelium-derived factor (PEDF) release u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernandez, Maria, Recalde, Sergio, Garcia-Garcia, Laura, Bezunartea, Jaione, Miskey, Csaba, Johnen, Sandra, Diarra, Sabine, Sebe, Attila, Rodriguez-Madoz, Juan Roberto, Pouillot, Severine, Marie, Corinne, Izsvák, Zsuzsanna, Scherman, Daniel, Kropp, Martina, Prosper, Felipe, Thumann, Gabriele, Ivics, Zoltán, Garcia-Layana, Alfredo, Fernandez-Robredo, Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909167/ https://www.ncbi.nlm.nih.gov/pubmed/31890733 http://dx.doi.org/10.1016/j.omtm.2019.10.013

Ejemplares similares

Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery
por: Garcia-Garcia, Laura, et al.
Publicado: (2017)

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids
por: Thumann, Gabriele, et al.
Publicado: (2017)

Molecular and Functional Characterization of BDNF-Overexpressing Human Retinal Pigment Epithelial Cells Established by Sleeping Beauty Transposon-Mediated Gene Transfer
por: Mattern, Larissa, et al.
Publicado: (2022)

The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells
por: Pastor, Marie, et al.
Publicado: (2017)

Enhanced Biosafety of the Sleeping Beauty Transposon System by Using mRNA as Source of Transposase to Efficiently and Stably Transfect Retinal Pigment Epithelial Cells
por: Harmening, Nina, et al.
Publicado: (2023)

Sleeping Beauty Transposon Insertions into Nucleolar DNA by an Engineered Transposase Localized in the Nucleolus
por: Kovač, Adrian, et al.
Publicado: (2023)

Vitamin D Protects against Oxidative Stress and Inflammation in Human Retinal Cells
por: Fernandez-Robredo, Patricia, et al.
Publicado: (2020)

Current Treatment Limitations in Age-Related Macular Degeneration and Future Approaches Based on Cell Therapy and Tissue Engineering
por: Fernández-Robredo, P., et al.
Publicado: (2014)

Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization
por: González-Zamora, Jorge, et al.
Publicado: (2023)

Retargeting transposon insertions by the adeno-associated virus Rep protein
por: Ammar, Ismahen, et al.
Publicado: (2012)

Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells
por: Turchiano, Giandomenico, et al.
Publicado: (2014)

Antiangiogenic and Neurogenic Activities of Sleeping Beauty-Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo
por: Johnen, Sandra, et al.
Publicado: (2015)

The expanding universe of transposon technologies for gene and cell engineering
por: Ivics, Zoltán, et al.
Publicado: (2010)

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells
por: Grabundzija, Ivana, et al.
Publicado: (2013)

Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells
por: Wang, Yongming, et al.
Publicado: (2014)

Correction: Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells
por: Turchiano, Giandomenico, et al.
Publicado: (2020)

Engineered Sleeping Beauty transposase redirects transposon integration away from genes
por: Miskey, Csaba, et al.
Publicado: (2022)

Correction: Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells
por: Wang, Yongming, et al.
Publicado: (2019)

Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes
por: Velazquez-Villoria, Alvaro, et al.
Publicado: (2016)

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers
por: Kolacsek, Orsolya, et al.
Publicado: (2011)

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers
por: Kolacsek, Orsolya, et al.
Publicado: (2013)

GMP-Grade Manufacturing and Quality Control of a Non-Virally Engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration
por: Kropp, Martina, et al.
Publicado: (2022)

Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration
por: Zhang, Wenli, et al.
Publicado: (2013)

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering
por: Voigt, Franka, et al.
Publicado: (2016)

Correction: Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration
por: Zhang, Wenli, et al.
Publicado: (2020)

Regulation of DNA transposition by CpG methylation and chromatin structure in human cells
por: Jursch, Tobias, et al.
Publicado: (2013)

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors
por: Holstein, Marta, et al.
Publicado: (2018)

A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming
por: Kesselring, Lisa, et al.
Publicado: (2020)

Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells
por: Kaufman, Christopher D, et al.
Publicado: (2005)

Matrix Metalloproteinase 10 Contributes to Choroidal Neovascularisation
por: González-Zamora, Jorge, et al.
Publicado: (2022)

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells
por: Gogol-Döring, Andreas, et al.
Publicado: (2016)

Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration
por: Hernandez, Maria, et al.
Publicado: (2021)

Evolution-guided evaluation of the inverted terminal repeats of the synthetic transposon Sleeping Beauty
por: Scheuermann, Barbara, et al.
Publicado: (2019)

Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial
por: García-Layana, Alfredo, et al.
Publicado: (2013)

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
por: Grabundzija, Ivana, et al.
Publicado: (2016)

A Cross-Sectional Observational Study of the Relationship between Outdoor Exposure and Myopia in University Students, Measured by Conjunctival Ultraviolet Autofluorescence (CUVAF)
por: Bilbao-Malavé, Valentina, et al.
Publicado: (2022)

RNA-guided retargeting of Sleeping Beauty transposition in human cells
por: Kovač, Adrian, et al.
Publicado: (2020)

Azithromycin reduces inflammation in a rat model of acute conjunctivitis
por: Fernandez-Robredo, Patricia, et al.
Publicado: (2013)

Transforming Growth Factor-Beta Inhibition Reduces Progression of Early Choroidal Neovascularization Lesions in Rats: P17 and P144 Peptides
por: Zarranz-Ventura, Javier, et al.
Publicado: (2013)

Germline Transgenic Pigs by Sleeping Beauty Transposition in Porcine Zygotes and Targeted Integration in the Pig Genome
por: Garrels, Wiebke, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ueqj8iks2gjuvktdg1iohuajfe