Low-Dose Busulfan Reduces Human CD34(+) Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice

Humanized animal models are central to efforts aimed at improving hematopoietic stem cell (HSC) transplantation with or without genetic modification. Human cell engraftment is feasible in immunodeficient mice; however, high HSC doses and conditioning limit broad use of xenograft models. We assessed...

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Detalles Bibliográficos
Autores principales: Leonard, Alexis, Yapundich, Morgan, Nassehi, Tina, Gamer, Jackson, Drysdale, Claire M., Haro-Mora, Juan J., Demirci, Selami, Hsieh, Matthew M., Uchida, Naoya, Tisdale, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909187/
https://www.ncbi.nlm.nih.gov/pubmed/31890735
http://dx.doi.org/10.1016/j.omtm.2019.10.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909187/
https://www.ncbi.nlm.nih.gov/pubmed/31890735
http://dx.doi.org/10.1016/j.omtm.2019.10.017

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