Vitamin D3 Is Transformed into 1,25(OH)(2)D(3) by Triggering CYP3A11(CYP3A4) Activity and Hydrolyzing Midazolam

BACKGROUND: Vitamin D3 (VD3) is a commonly used supplement in clinical practice. Cytochrome P450 3A11 (CYP3A11) is the most important monomeric enzyme involved in metabolism of drugs. This study aimed to investigate effects of vitamin D3 (VD3) on CYP3A11 activity. MATERIAL/METHODS: Forty male Spragu...

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Detalles Bibliográficos
Autores principales: Zhu, Hanfei, Wu, Ruihan, Gu, Zijun, Ji, Minghui, Xu, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910122/
https://www.ncbi.nlm.nih.gov/pubmed/31787743
http://dx.doi.org/10.12659/MSM.917904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910122/
https://www.ncbi.nlm.nih.gov/pubmed/31787743
http://dx.doi.org/10.12659/MSM.917904

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