Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity

Obesity is a clinical problem and an important adaptation in many species. Hibernating mammals, for example, become obese, insulin resistant, and hyperinsulinemic to store fat. Here, we combine comparative phylogenomics with large-scale human genome data to uncover candidate cis elements and genetic...

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Detalles Bibliográficos
Autores principales: Ferris, Elliott, Gregg, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910134/
https://www.ncbi.nlm.nih.gov/pubmed/31775032
http://dx.doi.org/10.1016/j.celrep.2019.10.102
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author Ferris, Elliott
Gregg, Christopher
author_facet Ferris, Elliott
Gregg, Christopher
author_sort Ferris, Elliott
collection PubMed
description Obesity is a clinical problem and an important adaptation in many species. Hibernating mammals, for example, become obese, insulin resistant, and hyperinsulinemic to store fat. Here, we combine comparative phylogenomics with large-scale human genome data to uncover candidate cis elements and genetic circuits in different cell types. The Fat Mass and Obesity (FTO) locus, the strongest genetic risk factor for human obesity, is an enriched site for hibernator pARs. Our results uncover noncoding cis elements with putative roles in obesity and hibernation.
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spelling pubmed-69101342019-12-13 Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity Ferris, Elliott Gregg, Christopher Cell Rep Article Obesity is a clinical problem and an important adaptation in many species. Hibernating mammals, for example, become obese, insulin resistant, and hyperinsulinemic to store fat. Here, we combine comparative phylogenomics with large-scale human genome data to uncover candidate cis elements and genetic circuits in different cell types. The Fat Mass and Obesity (FTO) locus, the strongest genetic risk factor for human obesity, is an enriched site for hibernator pARs. Our results uncover noncoding cis elements with putative roles in obesity and hibernation. 2019-11-26 /pmc/articles/PMC6910134/ /pubmed/31775032 http://dx.doi.org/10.1016/j.celrep.2019.10.102 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Ferris, Elliott
Gregg, Christopher
Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity
title Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity
title_full Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity
title_fullStr Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity
title_full_unstemmed Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity
title_short Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity
title_sort parallel accelerated evolution in distant hibernators reveals candidate cis elements and genetic circuits regulating mammalian obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910134/
https://www.ncbi.nlm.nih.gov/pubmed/31775032
http://dx.doi.org/10.1016/j.celrep.2019.10.102
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AT greggchristopher parallelacceleratedevolutionindistanthibernatorsrevealscandidateciselementsandgeneticcircuitsregulatingmammalianobesity

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