Isomeric triazines exhibit unique profiles of bioorthogonal reactivity

Expanding the scope of bioorthogonal reactivity requires access to new and mutually compatible reagents. We report here that 1,2,4-triazines can be tuned to exhibit unique reaction profiles with biocompatible strained alkenes and alkynes. Computational analyses were used to identify candidate orthog...

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Detalles Bibliográficos
Autores principales: Kamber, David N., Nguyen, Sean S., Liu, Fang, Briggs, Jeffrey S., Shih, Hui-Wen, Row, R. David, Long, Zane G., Houk, K. N., Liang, Yong, Prescher, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910137/
https://www.ncbi.nlm.nih.gov/pubmed/31908754
http://dx.doi.org/10.1039/c9sc01427f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910137/
https://www.ncbi.nlm.nih.gov/pubmed/31908754
http://dx.doi.org/10.1039/c9sc01427f

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