SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

PURPOSE: Mutations in RHO, the gene for a rhodopsin, are a leading cause of autosomal dominant retinitis pigmentosa. The objective of this study was to determine if a synthetic retinal analogue (SRD005825) serves as a pharmacologic chaperone to promote appropriate membrane trafficking of a mutant ve...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmed, Chulbul M., Dwyer, Brian T., Romashko, All, Van Adestine, Stev, Park, Eun-He, Lou, Zhe, Welty, Devi, Josiah, Seren, Savinainen, Annel, Zhang, Bohon, Lewin, Alfred S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910612/
https://www.ncbi.nlm.nih.gov/pubmed/31857914
http://dx.doi.org/10.1167/tvst.8.6.30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910612/
https://www.ncbi.nlm.nih.gov/pubmed/31857914
http://dx.doi.org/10.1167/tvst.8.6.30

Ejemplares similares