Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years. We show that human cells with extra chromosome engineere...

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Detalles Bibliográficos
Autores principales: Kneissig, Maja, Keuper, Kristina, de Pagter, Mirjam S, van Roosmalen, Markus J, Martin, Jana, Otto, Hannah, Passerini, Verena, Campos Sparr, Aline, Renkens, Ivo, Kropveld, Fenna, Vasudevan, Anand, Sheltzer, Jason M, Kloosterman, Wigard P, Storchova, Zuzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910827/
https://www.ncbi.nlm.nih.gov/pubmed/31778112
http://dx.doi.org/10.7554/eLife.50292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910827/
https://www.ncbi.nlm.nih.gov/pubmed/31778112
http://dx.doi.org/10.7554/eLife.50292

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