miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinnings promoting aberrant T cell activation remain poor...

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Detalles Bibliográficos
Autores principales: Scherm, Martin G., Serr, Isabelle, Zahm, Adam M., Schug, Jonathan, Bellusci, Saverio, Manfredini, Rossella, Salb, Victoria K., Gerlach, Katharina, Weigmann, Benno, Ziegler, Anette-Gabriele, Kaestner, Klaus H., Daniel, Carolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910913/
https://www.ncbi.nlm.nih.gov/pubmed/31836704
http://dx.doi.org/10.1038/s41467-019-13587-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910913/
https://www.ncbi.nlm.nih.gov/pubmed/31836704
http://dx.doi.org/10.1038/s41467-019-13587-3

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