Cargando…

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinnings promoting aberrant T cell activation remain poor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scherm, Martin G., Serr, Isabelle, Zahm, Adam M., Schug, Jonathan, Bellusci, Saverio, Manfredini, Rossella, Salb, Victoria K., Gerlach, Katharina, Weigmann, Benno, Ziegler, Anette-Gabriele, Kaestner, Klaus H., Daniel, Carolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910913/ https://www.ncbi.nlm.nih.gov/pubmed/31836704 http://dx.doi.org/10.1038/s41467-019-13587-3

Ejemplares similares

Short-term cold exposure supports human Treg induction in vivo
por: Becker, Maike, et al.
Publicado: (2019)

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
por: Scherm, Martin G., et al.
Publicado: (2019)

Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
por: Serr, Isabelle, et al.
Publicado: (2021)

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice
por: Serr, Isabelle, et al.
Publicado: (2016)

Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities
por: Serr, Isabelle, et al.
Publicado: (2021)

miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes
por: Scherm, Martin G., et al.
Publicado: (2020)

miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes
por: Scherm, Martin G., et al.
Publicado: (2020)

Generation and Validation of miR-142 Knock Out Mice
por: Shrestha, Amit, et al.
Publicado: (2015)

Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other
por: Scherm, Martin G., et al.
Publicado: (2022)

Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”
por: Daniel, Carolin, et al.
Publicado: (2017)

Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
por: Reißig, Sonja, et al.
Publicado: (2017)

Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
por: Daniel, Carolin, et al.
Publicado: (2011)

Coexpression Network Analysis of miRNA-142 Overexpression in Neuronal Cells
por: Thapa, Ishwor, et al.
Publicado: (2015)

A Novel Pathway of Flavonoids Protecting against Inflammatory Bowel Disease: Modulating Enteroendocrine System
por: Li, Mingrui, et al.
Publicado: (2022)

Effect of a Flavonoid Combination of Apigenin and Epigallocatechin-3-Gallate on Alleviating Intestinal Inflammation in Experimental Colitis Models
por: Li, Mingrui, et al.
Publicado: (2023)

Regulation of T Follicular Helper Cells in Islet Autoimmunity
por: Serr, Isabelle, et al.
Publicado: (2018)

Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation
por: Kim, Rinho, et al.
Publicado: (2016)

Regulation of the intestinal immune system by flavonoids and its utility in chronic inflammatory bowel disease
por: Hoensch, Harald Peter, et al.
Publicado: (2018)

MiRNA-128 and MiRNA-142 Regulate Tumorigenesis and EMT in Oral Squamous Cell Carcinoma Through HOXA10
por: Yao, Yao, et al.
Publicado: (2020)

miR-142-3p regulates autophagy by targeting ATG16L1 in thymic-derived regulatory T cell (tTreg)
por: Lu, Yunjie, et al.
Publicado: (2018)

Biodegradable Polymeric Nanoparticles Loaded with Flavonoids: A Promising Therapy for Inflammatory Bowel Disease
por: Li, Mingrui, et al.
Publicado: (2023)

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker
por: Pantier, Raphaël, et al.
Publicado: (2019)

Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis
por: Lechner, Kristina S., et al.
Publicado: (2020)

miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis
por: Li, Genpeng, et al.
Publicado: (2023)

Altered expression and editing of miRNA-100 regulates iTreg differentiation
por: Negi, Vinny, et al.
Publicado: (2015)

Coulomb Excitation of $^{142}$Xe
por: Henrich, C, et al.
Publicado: (2018)

142nd SPSC Meeting
Publicado: (2021)

142nd LHCC Meeting
Publicado: (2020)

Serum miRNA-142 and BMP-2 are markers of recovery following hip replacement surgery for femoral neck fracture
por: Gao, Haoyuan, et al.
Publicado: (2020)

The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent
por: Al-Amily, Israa Mohammad, et al.
Publicado: (2019)

The Memory T Cell “Communication Web” in Context with Gastrointestinal Disorders—How Memory T Cells Affect Their Surroundings and How They Are Influenced by It
por: Knauss, Annkathrin, et al.
Publicado: (2022)

Measurement of the decay scheme of $^{142}$Cs
por: Jones, P; iThemba LABS
Publicado: (2020)

Minutes of the 142nd Meeting of the LHCC
por: CERN. Geneva. Large Hadron Collider Experiments Committee, et al.
Publicado: (2020)

Health Tract, No. 142: Eating Habits
Publicado: (1863)

Health Tract, No. 142: Eating Habits
Publicado: (1865)

Nanog-dependent function of Tet1 and Tet2 in establishment of pluripotency
por: Costa, Yael, et al.
Publicado: (2013)

TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
por: Berrout, Jonathan, et al.
Publicado: (2017)

Evaluation of the COBAS Core II immunochemistry analyser
por: Kötting, Jochem, et al.
Publicado: (1996)

Loss of TET2 and TET3 in regulatory T cells unleashes effector function
por: Yue, Xiaojing, et al.
Publicado: (2019)

TET2 and TET3 loss disrupts small intestine differentiation and homeostasis
por: Ansari, Ihab, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_h2di002jmpsb9le6hb09hpksqf