Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance

Emtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors (NRTIs) in anti-HIV therapy. Treatment with FTC or 3TC primarily selects for the HIV-1 RT M184V/I resistance mutations. Here we pro...

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Detalles Bibliográficos
Autores principales: Hung, Magdeleine, Tokarsky, E. John, Lagpacan, Leanna, Zhang, Lijun, Suo, Zucai, Lansdon, Eric B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910994/
https://www.ncbi.nlm.nih.gov/pubmed/31872074
http://dx.doi.org/10.1038/s42003-019-0706-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910994/
https://www.ncbi.nlm.nih.gov/pubmed/31872074
http://dx.doi.org/10.1038/s42003-019-0706-x

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