Cargando…

Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance

Emtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors (NRTIs) in anti-HIV therapy. Treatment with FTC or 3TC primarily selects for the HIV-1 RT M184V/I resistance mutations. Here we pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hung, Magdeleine, Tokarsky, E. John, Lagpacan, Leanna, Zhang, Lijun, Suo, Zucai, Lansdon, Eric B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910994/ https://www.ncbi.nlm.nih.gov/pubmed/31872074 http://dx.doi.org/10.1038/s42003-019-0706-x

Ejemplares similares

The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance
por: Acosta-Hoyos, Antonio J., et al.
Publicado: (2010)

Allosteric Regulation of HIV-1 Reverse Transcriptase by ATP for Nucleotide Selection
por: Yokoyama, Masaru, et al.
Publicado: (2010)

Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance
por: Xu, Hong-Tao, et al.
Publicado: (2009)

Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase
por: Nakamura, Akiyoshi, et al.
Publicado: (2015)

Nucleotide modification at the γ-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase
por: Mulder, Brent A., et al.
Publicado: (2005)

Assessment of Telomerase Reverse Transcriptase Single Nucleotide Polymorphism in Sleep Bruxism
por: Macek, Piotr, et al.
Publicado: (2022)

Naringin Reverses Hepatocyte Apoptosis and Oxidative Stress Associated with HIV-1 Nucleotide Reverse Transcriptase Inhibitors-Induced Metabolic Complications
por: Adebiyi, Oluwafeyisetan O., et al.
Publicado: (2015)

Base Preferences in Non-Templated Nucleotide Incorporation by MMLV-Derived Reverse Transcriptases
por: Zajac, Pawel, et al.
Publicado: (2013)

Deformation change between $^{184m}$Au and $^{184g}$Au
por: Roussière, B, et al.
Publicado: (1998)

Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases
por: Álvarez, Mar, et al.
Publicado: (2017)

NMR characterization of HIV-1 reverse transcriptase binding to various non-nucleoside reverse transcriptase inhibitors with different activities
por: Thammaporn, Ratsupa, et al.
Publicado: (2015)

Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
por: Warren, Kylie, et al.
Publicado: (2009)

Docking study of HIV-1 reverse transcriptase with phytochemicals
por: Seal, Abhik, et al.
Publicado: (2011)

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
por: Smith, Steven J., et al.
Publicado: (2014)

Asymmetric conformational maturation of HIV-1 reverse transcriptase
por: Zheng, Xunhai, et al.
Publicado: (2015)

Architecture of an HIV-1 reverse transcriptase initiation complex
por: Larsen, Kevin P., et al.
Publicado: (2018)

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
por: Rhee, Soo-Yon, et al.
Publicado: (2016)

Approved HIV reverse transcriptase inhibitors in the past decade
por: Li, Guangdi, et al.
Publicado: (2022)

REverSe TRanscrIptase chain termination (RESTRICT) for selective measurement of nucleotide analogs used in HIV care and prevention
por: Olanrewaju, Ayokunle O., et al.
Publicado: (2022)

Utilization of a Deoxynucleoside Diphosphate Substrate by HIV Reverse Transcriptase
por: Garforth, Scott J., et al.
Publicado: (2008)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2008)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2009)

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase
por: Masuda, Takao, et al.
Publicado: (2022)

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase
por: Kirby, Thomas W., et al.
Publicado: (2023)

Investigating the Conformational Dynamics of a Y-Family DNA Polymerase during Its Folding and Binding to DNA and a Nucleotide
por: Chu, Xiakun, et al.
Publicado: (2021)

Multicenter study of skin rashes and hepatotoxicity in antiretroviral-naïve HIV-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside reverse-transcriptase inhibitors in Taiwan
por: Wu, Pei-Ying, et al.
Publicado: (2017)

Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance
por: Bertoletti, Nicole, et al.
Publicado: (2020)

A reverse transcriptase ribozyme
por: Samanta, Biswajit, et al.
Publicado: (2017)

Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors
por: Boyce, Sarah E., et al.
Publicado: (2014)

Reverse transcriptase activity in psoriatic lesions: effects of reverse transcriptase inhibitors on keratinocyte proliferation and differentiation
por: Molès, Jean-Pierre, et al.
Publicado: (2009)

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
por: Mirambeau, Gilles, et al.
Publicado: (2007)

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase
por: Singh, Kamalendra, et al.
Publicado: (2010)

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity
por: Ilina, Tatiana, et al.
Publicado: (2012)

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
Publicado: (2014)

Design and synthesis of tetrahydrophthalimide derivatives as inhibitors of HIV-1 reverse transcriptase
por: Penta, Ashok, et al.
Publicado: (2013)

Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase
por: Figiel, Małgorzata, et al.
Publicado: (2018)

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase
por: Meleddu, Rita, et al.
Publicado: (2016)

HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data
por: Tarasova, Olga, et al.
Publicado: (2018)

Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
por: Famiglini, Valeria, et al.
Publicado: (2016)

The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity
por: Drosopoulos, William C., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ne1phlibgh3ubg6m1hv2ndah5o