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hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen

Neuroendocrine prostate cancer (NEPC) is thought to arise as prostate adenocarcinoma cells transdifferentiate into neuroendocrine (NE) cells to escape potent anti-androgen therapies however, the exact molecular events accompanying NE transdifferentiation and their plasticity remain poorly defined. C...

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Detalles Bibliográficos
Autores principales: Fraser, Jennifer A., Sutton, Joseph E., Tazayoni, Saba, Bruce, Isla, Poole, Amy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911083/
https://www.ncbi.nlm.nih.gov/pubmed/31836808
http://dx.doi.org/10.1038/s41598-019-55665-y