Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide

Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription could elicit their instability; however, the underlying mechanisms remain e...

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Detalles Bibliográficos
Autores principales: Brison, Olivier, El-Hilali, Sami, Azar, Dana, Koundrioukoff, Stéphane, Schmidt, Mélanie, Nähse, Viola, Jaszczyszyn, Yan, Lachages, Anne-Marie, Dutrillaux, Bernard, Thermes, Claude, Debatisse, Michelle, Chen, Chun-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911102/
https://www.ncbi.nlm.nih.gov/pubmed/31836700
http://dx.doi.org/10.1038/s41467-019-13674-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911102/
https://www.ncbi.nlm.nih.gov/pubmed/31836700
http://dx.doi.org/10.1038/s41467-019-13674-5

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