Deciphering essential cistromes using genome-wide CRISPR screens

Although millions of transcription factor binding sites, or cistromes, have been identified across the human genome, defining which of these sites is functional in a given condition remains challenging. Using CRISPR/Cas9 knockout screens and gene essentiality or fitness as the readout, we systematic...

Descripción completa

Detalles Bibliográficos
Autores principales: Fei, Teng, Li, Wei, Peng, Jingyu, Xiao, Tengfei, Chen, Chen-Hao, Wu, Alexander, Huang, Jialiang, Zang, Chongzhi, Liu, X. Shirley, Brown, Myles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911175/
https://www.ncbi.nlm.nih.gov/pubmed/31727847
http://dx.doi.org/10.1073/pnas.1908155116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911175/
https://www.ncbi.nlm.nih.gov/pubmed/31727847
http://dx.doi.org/10.1073/pnas.1908155116

Ejemplares similares